Jobs

Head of Computational Chemistry


Job details
  • CK Group
  • Cambridge
  • 3 months ago
Applications closed

Head of Computational Chemistry

Job Title:Head of Computational Chemistry

Location:Hybrid, Cambridge

Salary:Competitive salary and benefits

Description:

We have an exceptional opportunity for an experienced computational chemist and drug hunter to lead the Computational Chemistry team at Nxera Pharma (formerly Sosei Heptares).

This is an exciting position, leveraging the NxWave platform to lead application of computational approaches in drug discovery projects and develop novel, computational methodology, for wider utility. 

COMPANY:

Nxera Pharma is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally, focused on therapeutic areas in inflammation diseases, neurology and immunology.

In addition to several products being commercialized in Japan, they are advancing an extensive pipeline of over 30 active programs from discovery through to late clinical stage internally and in partnership with leading pharma and biotech companies including Lilly, GSK, AbbVie, Verily, Neurocrine, Takeda, Genentech/Roche, Pfizer, Boehringer Ingelheim, Medicxi, Aditum Bio.

This pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery “NxWave” platform to provide a sustainable source of best- or first-in-class candidates.

RESPONSIBILITIES:

This is an influential leadership post in a highly collaborative environment. The successful applicant will manage a team of computational chemists supporting a diverse portfolio of internal and partnered projects. They will also play an active role as a member of the Discovery leadership team, using their knowledge and experience to contribute to growing the function and influencing R&D and company strategy.

In this role, the successful candidate will:

Ensure scientific excellence of the computational chemistry team through effective line-management and mentoring, supporting delivery of key internal and partnered milestones. Work with key stakeholders across other disciplines in Nxera Pharma to influence R&D strategy and define and execute high quality computational strategies that enhance delivery of projects across the portfolio. Drive continuous growth and development of cutting-edge SBDD & CADD methodologies. Lead implementation of innovative computational solutions (e.g. ML/AI workflows) that add value in the NxWave drug design process. Support growth of our NxStaR Platform Technology by implementation of machine learning and AI approaches for in silico protein design.

QUALIFICATIONS:

As Head of Computational Chemistry you will require:

Demonstrable leadership skills and the ability to lead a team of experienced computational scientists. Track record of impactful contributions within relevant sector(s) including pharma, biotech, academia, CRO. Evidence of broad expertise in computational sciences with an emphasis on structure-based drug design (including GPCRs), ligand- and structure-based virtual screening, cheminformatics, and machine learning. Demonstrable technical excellence in aspects of predictive modelling (AI/ML), such as: QSAR, active learning, molecular generation, etc. Track record of identifying, developing, and applying innovative solutions to scientific and technological problems faced in computational molecular design and in the wider drug discovery organisation. Extensive knowledge of related disciplines (e.g. chemistry, biology, DMPK, safety) with demonstrable evidence of developing and implementing new scientific strategies in collaboration. Proficiency in membrane protein structural modelling using the latest AI implementations. Evidence of influencing project and organisational scientific strategy. Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines and external partners with a positive, collegial, collaborative attitude.

BENEFITS:

Competitive salary and benefits package.

Sign up for our newsletter

The latest news, articles, and resources, sent to your inbox weekly.

Similar Jobs

Head of Computational Chemistry

Head of Computational ChemistryJob Title:Head of Computational ChemistryLocation:Hybrid, CambridgeSalary:Competitive salary and benefitsDescription:We have an exceptional opportunity for an experienced computational chemist and drug hunter to lead the Computational Chemistry team at Nxera Pharma (formerly Sosei Heptares).This is an exciting position, leveraging the NxWave platform to lead application of computational approaches...

CK Group Cambridge

Research Fellow

Directorate: School of Engineering & Physical SciencesSalary: Grade 8 (£45,585-£56,021)Contract Type:Full Time (1FTE), Fixed Term (36 Months)Detailed DescriptionApplicants should hold a PhD in Chemical Engineering, Biochemistry, Chemistry or a related subject and have substantial experience in molecular modelling with either dynamics simulations and/or molecular based equations of state. Applicants will...

Heriot-Watt University Midlothian

Industrial PostDoc - Materials Science - 2 Year Contract

 Requisition #: 14949 Our Mission: Powering Innovation That Drives Human Advancement  When visionary companies need to know how their world-changing ideas will perform, they close the gap between design and reality with Ansys simulation. For more than 50 years, Ansys software has enabled innovators across industries to push boundaries by...

Ansys Cambridge

Senior Product Manager - AI/ML

Job descriptionPurpose of OnyxThe Onyx Research Data Platform organization represents a major investment by GSK R&D and Digital & Tech, designed to deliver a step-change in our ability to leverage data, knowledge, and prediction to find new medicines.    We are a full-stack shop consisting of product and portfolio leadership, data...

GSK London

Senior Principal Scientist, Research Analytics

Make your mark for patientsUCB is seeking a talented and experienced Senior Principal Scientist to join our Research Analytics team in Slough, United KingdomAbout the roleAs a key member of the Research Analytics group, you will play a pivotal role in advancing UCB's drug discovery and development efforts by applying...

UCB Slough

Data Architecture Lead, Life Science

Make your mark for patientsWe are looking for a Data Architect Lead who is highly motivated data driven and passionate to join us in our Data Enablement team, based in our Slough office in the UK.About the roleWe are looking for a highly motivated hands-on leader to work with teams...

UCB Slough