Head of Clinical Sciences

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Your impact
The experienced Head of Clinical Sciences will be the strategic architect of our clinical programs, leading studies from first in human (FIH) to proof-of-concept to registration. The role ensures clinical programs are aligned with corporate objectives, strategically designed, and deliver decision-ready data . Reporting to the Chief Medical Officer, this role will lead the protocol design and study delivery strategy. This role will work in close collaboration to establish, lead, and execute on the clinical development plan(s), and will have the opportunity to drive strategic decision-making to maximize the value of current and future clinical programs. Beyond the data, this role will champion a culture of scientific excellence, setting the bar for rigor and accountability as we scale our pipeline to reach patients faster.

What you will do

• Lead the global clinical science strategy, endpoint selection, end-to-end protocol development, and associated amendment(s) across the full trial lifecycle, ensuring high level of quality and operational delivery.
• Spearhead the end-to-end clinical data review process, synthesizing complex data to deliver evidence-based strategic recommendations to executive leadership.
• Accountable for safety monitoring and risk management strategies, interpreting safety/efficacy data to guide critical decisions.
• Author and review key clinical and regulatory documents.
• Facilitate cross-functional collaboration to transition research stage assets to clinical development and integrate translational insights to influence broader program strategy.
• Represent the organization in health authority interactions and lead the scientific rationale for regulatory responses.
• Build and maintain strategic relationships with external partners (e.g., Key Opinion Leaders, Principal Investigators, and CROs) to validate program direction and support investor relations activities.
• Define and implement scalable clinical science best practices, SOPs, and governance frameworks to ensure speed, consistency, and inspection readiness.
• Define the unifying scientific messaging across internal and external stakeholders, supporting publication strategies and commercial positioning.
• Collaborate with internal AI/ML teams to identify and implement technology-driven solutions to enhance scientific literature analysis, clinical data interpretation, and overall operational efficiency.
• Requires some travel.

Skills and qualifications

Essential:

• Education: Advanced degree (MD, PhD, PharmD).
• Experience: 15+ years in the pharmaceutical/biotech industry, with a proven track record in small to mid-sized startup environments. Deep expertise in oncology or inflammation.
• Track record: Proven success in leading programs from IND through late stage development. Experience leading successful regulatory filings.
• Scientific Rigor: Strategic ability to interpret complex, ambiguous datasets to drive corporate strategy and mitigate development risks.
• Leadership Effectiveness: Demonstrated success in a fast-paced matrixed environment. Strong interpersonal skills with the ability to influence without authority and resolve conflicts across global functions.

Preferred:

• The Builder: Comfort in a fast-paced, evolving start up with experience building foundational capabilities from scratch.
• The Diplomat: A master of cross-functional influence who can build consensus and navigate complex governance with high emotional intelligence.
• The Innovator: Knowledge of industry trends and technologies to drive competitive advantage, leveraging automation or digital tools to simplify workflows and accelerate the path to patients.

Closing date: 21 April

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, andwould require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

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