Job description
Site Name:UK - Hertfordshire - Stevenage, Cambridge 300 Technology Square, Heidelberg - Office, USA - Pennsylvania - Upper Providence
Posted Date:Dec 2 2024

This position may be based at a GSK R&D site in UK (Stevenage), in USA (Cambridge Tech Square, MA; or Upper Providence, PA), or in Germany (Heidelberg).

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology, and disease mechanisms, and transform medical discovery.  We are revolutionising the way we do R&D. We’re uniting science, technology, and talent to get ahead of disease together.

Find out more:

Our approach to R&D.   

There is currently an exciting opportunity for a Principal/Scientific Investigator join theGenomic Technologiesteam and work on projects aligned to current areas of focus, contributing to methodological, algorithmic, computational and data aspects for:

• Discovery of new causal gene-phenotype links through analysis of large-scale individual level human genetic data and GWAS/xQTL summary statistics, and predictive modelling approaches to integrate genetic and ‘omic data.

• Inference of causal networks and disease-relevant mechanisms through analysis and integration of cellular, transcriptomic, and multi-omic data from genome-scale gene editing perturbation experiments.

• Identification of causal genes, disease-relevant mechanisms and cell types, potential drug targets, candidate biomarkers, patient subgroups and disease subtypes, through integration of genetic association data across multiple ‘omic and phenotypic layers.

In this role you will…

• Contribute to design, oversight, development and maintenance of the computational and data infrastructure integrating pipelines, software, and databases for individual and summary-level genetic and genomic data, external and internal databases, and user interfaces.

• Build and maintain close collaboration and effort coordination with other departments providing and supporting software industrialization, database design and maintenance, cloud computing and other IT infrastructure.

• Support and co-lead dynamic project-based multifunctional teams implementing best-in-class approaches for genetic and genomic data analysis, acrossGenomic Technologieslines and in collaboration with scientists in Data and Predictive Sciences, Biostatistics and AI/ML teams.

• Champion reproducible research, literate programming, best coding and software development practices, FAIR principles.

• Staying informed about recent research and developments in the field and considering its potential for application within GSK.

• Contributing to a culture of innovation, quality, and willingness to learn and improve.

Why you?

Required Qualifications & Skills:

• Advanced degree (PhD or equivalent) in a relevant scientific discipline.

• Excellent programming skills, and knowledge of techniques in reproducible research, literate programming, FAIR data principles, and software development, as well as tools supporting these best practices.

• Demonstrated experience of delivery of complex projects, supervision and coordination of efforts of multifunctional teams; preferably in the at-scale genetic/genomic data analytic area.

• Experience with cloud computing and database technologies(e.g. SQL, PySpark, BigQuery, Docker, Nextflow).

• Experience of evaluating, improving, testing, and/or developing methods for analysis and interpretation of large-scale genetics or genomics data.

• Strong communication and team-working skills.

Preferred Skills & Experience:

• Experience with machine learning and/or advanced statistical methods.

• Experience working in multidisciplinary teams on complex and impactful projects.

• Experience with integrating information across multiple genetic, genomic, epigenomic, or experimental/functional genomic data types.

• Experience in Agile/Scrum development framework.

• Experience with DevOps.

Closing date: 23/12/2024

Successful candidates will detail in their applications how their personal qualifications, skills and experience make them ideally suited to the specific responsibilities and requirements of the role. 

Please take a copy of the Job Description, as this will not be available post closure of the advert.

We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. 

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work. 

Discover more about our company wide benefits and life at GSK on our webpageLife at GSK | GSK

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or . 

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click thelinkand scroll to the Careers Section where you will find answers to multiple questions we receive.

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it.  Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

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