Principal Scientist

Site Name:UK - Hertfordshire - Stevenage
Posted Date:Mar 21 2025

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We are looking for a highly motivated scientist with experience in onco-immunology and cellular biology and flow cytometry to join the Oncology Translational Research team within GSK Oncology TA.

The Oncology Translational Research team will partner with Oncology TA team members to increase clinical translatability and to contribute to preclinical development programs within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting allogenic/autologous patient-derived PBMC alone or in combination with patient-derived organoids, is analyzing downstream immune response, developing, and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

Key responsibilities

This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:

• Setting up and performing immune cells-based in vitro assays (including activation, proliferation, and phenotype characterization).
• Planning and executing in vitro studies with patient-derived organoids and allogenic/autologous immune cells
• Executing flow cytometry staining, data collection and analysis (above 10 colors)
• Supporting and performing multimodality experiments according to the DBT lab project.
• Collecting and reporting data to the lab head and solving technical issues as part of a cross-functional project team.
• Collaborating with KCL scientists within the GSK-KCL Translational Oncology Research Hub, an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• BSc in Cell Biology/Immunology/Oncology or related, + a multidisciplinary mix of training/expertise in Oncology and immunology.
• Proven expertise in T cell biology in tumor immune microenvironment and in immunotherapy.
• Significant experience in cell culture techniques (immune cells and primary samples/ patient-derived organoids).
• Extensive experience in multiple colors flow cytometry.
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units.
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• PhD in Biology/Oncology
• A track record of scientific publication.

Closing Date for Applications - 28th of March 2025(COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

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