Job description
Site Name:UK - Hertfordshire - Stevenage
Posted Date:Jan 27 2025
We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programs, pension plan membership, and shares and savings program.
We embrace modern work practices; our Performance with Choice program offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.
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Investigator, Exosomes
We are looking for a highly motivated scientist with experience in extracellular vesicles (i.e. exosome) isolation and characterisation to join the Oncology Translational Research team in GSK.
The Oncology Translational Research team will partner with Oncology TA team members to increase clinical translatability and to contribute to preclinical development programs within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting patient-derived organoids, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.
Job Purpose
In this role you will
- Isolate and purify exosomes from patient-derived samples including organoids, blood samples and tissues using ultracentrifugation and other methods.
- Analyse exosomes characteristics (including but not limited to concentration, zeta potential, size) and exosomes content (proteins, DNA, RNA).
- Setting up protocol for exosomes characterisation by flow cytometry (NanoFCM).
- Managing more junior team members and train them on exosomes protocols.
- Collaborate and solve technical issues operating as part of a cross-functional project team involved in translational research.
- Execute and deliver data of the project to a high quality and within define time-frames.
Why you?
Basic Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
- BSc in Cell Biology/Oncology or related discipline withdemonstrated experiencein extracellular vesicles (in particular exosomes) isolation and characterisation.
- Strong experience with relevant techniques such as flow cytometry (NanoFCM) and nanoparticle tracking.
- A track record of scientific publications in the EV area.
- Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude.
- Prior experience of managing or mentoring junior members in a laboratory.
Preferred Qualifications & Skills:
Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:
- Preferred MSc or PhD.
- Strong understanding of cancer biology, including the molecular mechanisms underlying tumorigenesis and cancer progression.
- Experience with the following techniques: tapestation for DNA analysis, automated western blotting.
- Strong strategic thinking and problem-solving skills, with the ability to navigate complex scientific and business challenges.
Closing Date for Applications – 09/02/25
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
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