Group Leader – DMPK

Cambridge, full time

Permanent

Up to £76k per annum (depending on skills, background and experience)

This is an integral role which requires impact and a purposeful approach in bothin vitroandin vivoexperimental science projects across the DMPK drug discovery process.

Core role requirements will include:

• Suggest, craft and carry out innovative experiments within an expert team of DMPK and PKPD Scientists.
• Monitor and maintain an up-to-date awareness of progression in the DMPK and PKPD sector, suggesting next steps in the experimental process and evaluation of novel techniques.
• Contribute, along with other senior team, to the leadership of the Medicinal Chemistry and DMPK group and the Therapeutic innovation strategy.
• Manage outsourcing activity and operational resources to ensure effective delivery of projects.
• Oversee internal expertise, apportioning capacity and resources which inform governance and decision-making around portfolio support and technology development.
• Ensure consistent high-quality data integrity within the DMPK group, presenting compelling data interpretation to guide research strategy and direction.
• Lead and manage drug discovery projects as appropriate and act as the interface between a number of operational teams and cross-site initiatives.

Your background:

• PhD or equivalent in Pharmaceutics, Pharmacology, Drug Metabolism or Pharmacokinetics (or closely related) – must cover a deep and broad element of modelling and simulation (quantitative pharmacology, systems biology, pharmacometrics, applied maths for example)
• Proven expertise in the DMPK space for drug discovery
• Demonstrable track record of delivering PK, PKPD and TKPD expertise to projects including mechanistic PKPD modelling for therapeutic dose prediction
• Highly skilled in use of MATLAB, SimCYP, WinNonLin/Phoenix NLME
• You will bring a wide and varied personal network; accustomed to presenting and publishing your work in recognised leading journals
• Strong influencing skills, able to lead with credibility and compelling communication skills, both in person and written form
• Accustomed to working in a diverse team setting across multiple sites with both internal and external stakeholders to consider
• Strategic, innovative and collaborative in all your interactions and decision-making responsibilities, with a solid track record of delivering significant results in the DMPK space

If this describes you and your background, as well as the direction of travel for your next step, then apply here or contact us for more information: /