Antibody Discovery and Engineering Scientist

Next-Link
Slough
2 months ago
Applications closed

Role overview
Our Client are world leaders in antibody drug discovery and development. This is a unique opportunity to join the Antibody Discovery team working with cutting edge technologies to help shape delivery of next generation antibody therapeutics.

This is an excellent opportunity to join a dynamic and thriving team of scientists helping to develop and validate new sequencebased and structurebased antibody design approaches. This includes elements of antibody hit identification sequence optimisation and in silico de novo antibody design. This is a laboratorybased role where a detailed knowledge of molecular biology and microbiological methods and a proven track record of antibody discovery or protein engineering would be a significant advantage.

Responsibilities
Play a key role in the discovery of therapeutic monoclonal antibodies to support pipeline and help create value for patients suffering with serious disease.
Using cuttingedge yeast display for the discovery and optimisation of human antibodies aligned with therapeutic targets.
Design construct and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimisation projects.
The preparation of next generation sequencing (NGS) libraries and their analyses to support antibody discovery and engineering of lead molecules.
Working closely with computational and CADD scientists codevelop and apply AI/Deep learning solutions and structurebased approaches to facilitate discovery and engineering of highquality antibody molecules.
Contribute to the development and implementation of new methodologies in antibody display and engineering.
Work flexibly across project teams to ensure delivery of results against expected timelines.
Present experimental data at crossfunctional meetings.



Requirements

Profile
A PhD (or equivalent) with molecular biology and protein biochemistry knowledge ideally within the antibody space.

Knowledge and experience in the use of in vitro display libraries for either discovery affinity maturation or other protein engineering preferably to include structure or deep sequenceguided insight would be desirable.

Demonstrable experience of biochemical techniques for the characterisation of macromolecules such as flowcytometry surface plasmon resonance or Biolayer interferometry would be beneficial.

Skills in informatic and other computational platforms such as molecular visualisation and next generation sequencing data analysis would be advantageous.

Highly motivated with excellent attention to detail and critical data analysis skills.

A trusted ability to deliver to deadlines.

Excellent communication skills.


Commercial training, business studies or similar training Excellent knowledge of German, English and French (spoken and written), knowledge of Italian an advantage Several years of experience in customer service, preferred in the health care industry IT affinity in dealing with ERP systems (SAP and salesforce.com) and MS Office, e-commerce experience (EDI, web shop, GHX) an advantage Empathetic and friendly personality who stays calm even in the hustle and bustle combined with the ability to maintain focus even under rapidly changing situations and topics or under pressure Please note: Sales Order Management Exp is a must have! Candidate has to be available as of immediate or max within 4 weeks. No remote work, the person has to be present at the site in Rotkreuz.
Key Skills
Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills
Employment Type :Full Time
Experience:years
Vacancy:1

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