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Machine Learning Performance Engineer, London London

Isomorphic Labs Limited
London
1 week ago
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Machine Learning Performance Engineer, London

London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Machine Learning Performance Engineer, LondonYour impact

This is an exciting opportunity for you to contribute to frontier research at the intersection of AI and drug design.

Working in a highly creative, iterative environment, you will join the model performance and scaling team, where you will partner with scientists and engineers to scale foundational models that will transform the biopharmaceutical world as we know it.

You will draw upon your existing engineering experience whilst learning from those around you, to apply novel techniques and ideas to newly encountered model and systems performance optimizations, as well as machine learning, computational biology and chemistry problems.

What you will do

Develop custom GPU kernels maximising utilisation and application performance.

Help design, implement, and optimize distributed training and inference strategies.

Implement low-level optimisations to overcome hardware limitations.

Diagnose and debug performance bottlenecks to optimize latency and throughput, impacting real world drug design programs.

Design low-precision algorithms balancing high performance with minimal accuracy loss.

Collaborate with researchers to create efficient training and inference model architectures.

Skills and qualifications

Significant industry experience and strong working knowledge of HPC and ML systems.

Good understanding of GPU and other AI accelerator architectures.

Strong knowledge of data structures and algorithms.

Experience with deep learning ML frameworks (preferably JAX).

Nice to have:

Knowledge of XLA, Triton, Pallas, CUDA or similar accelerator DSLs / compiler stacks.

Experience with distributed training and data/model sharding strategies.

Knowledge of collective communication libraries (e.g. NCCL).

Experience with optimising ML accuracy using low-precision formats.

Experience building, deploying and maintaining production systems on GCP.

Interest in chemistry and biology.


Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.


Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, andwould require you to be able to come into the office 3 days a week(currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy .

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As an AI-first company, we embrace tools like Gemini. However, our interview process is designed to understand your unique expertise and problem-solving skills, as well as what motivates you.Therefore, we ask that you refrain from using any AI tools, transcription services, or other assistants during your interview and assessment process, unless you've made prior arrangements with our Talent team for specific needs or accommodations. (If you require any adjustments, please discuss this with the Talent team during your initial screening call.) *

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Iso Demographic Questions

We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact. We are working to build teams that reflect and represent the populations we are striving to serve. As part of this effort we would like to better understand our candidate audience, so that we can continue to improve.

We need your help to do this, butfilling in this form is entirely voluntary. You may choose not to provide the requested demographic information. Whether you choose to provide the information or not, this will be kept separate from your application and will have no bearing on any hiring decision.

Any demographic information you provide will beanonymised and held separately from your application. No Isomorphic Labs hiring decision makers will have access to this information and the information will only be used for aggregated reporting and monitoring purposes, not for the purposes of your application or making any hiring decisions. You can find more information about how we process diversity and demographic information in our Applicant and Candidate Privacy Notice .

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